Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol)
نویسندگان
چکیده
منابع مشابه
Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol)
BACKGROUND Management and choice of sedation is important during critical illness in order to reduce patient suffering and to facilitate the delivery of care. Unfortunately, medications traditionally used for sedation in the intensive care unit (ICU) such as benzodiazepines and propofol are associated with significant unwanted effects. Clonidine is an alpha-2 selective adrenergic agonist that m...
متن کاملClonidine for sedation in the critically ill: a systematic review and meta-analysis
BACKGROUND This systematic review and meta-analysis investigates the efficacy and safety of clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation. METHODS We performed a comprehensive search of MEDLINE, EMBASE, CINAHL and the Cochrane trial registry. We identified RCTs that compared clonidine to any non-clonidine regimen in critically ill patients, exclu...
متن کاملComparison of sedation strategies for critically ill patients: a protocol for a systematic review incorporating network meta-analyses
BACKGROUND Sedatives and analgesics are administered to provide sedation and manage agitation and pain in most critically ill mechanically ventilated patients. Various sedation administration strategies including protocolized sedation and daily sedation interruption are used to mitigate drug pharmacokinetic limitations and minimize oversedation, thereby shortening the duration of mechanical ven...
متن کاملPhysical therapy for the critically ill in the ICU: a systematic review and meta-analysis.
OBJECTIVE The purpose of this systematic review was to review the evidence base for exercise in critically ill patients. DATA SOURCES AND STUDY SELECTION Using keywords critical care and physical therapy and related synonyms, randomized controlled trials, meta-analyses, and systematic reviews were identified through electronic database searches and citation tracking. Clinical trials with outc...
متن کاملBenzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials.
BACKGROUND Use of dexmedetomidine or propofol rather than a benzodiazepine sedation strategy may improve ICU outcomes. We reviewed randomized trials comparing a benzodiazepine and nonbenzodiazepine regimen in mechanically ventilated adult ICU patients to determine if differences exist between these sedation strategies with respect to ICU length of stay, time on the ventilator, delirium prevalen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Systematic Reviews
سال: 2015
ISSN: 2046-4053
DOI: 10.1186/s13643-015-0139-7